What is the best treatment for porokeratosis?
Porokeratosis of Mibelli showed the best outcomes after treatment with imiquimod cream and linear PK responded well to topical or systemic retinoids. Topical vitamin D acid derivatives may be the best therapeutic option for disseminated PK.
What causes porokeratosis?
The exact cause of porokeratosis is not known, but genetic factors and having a weak immune system may put you at a greater risk for the condition. Sunlight, UV rays, and other radiation worsen the condition.
Is porokeratosis autoimmune?
The development of disseminated superficial porokeratosis is occasionally observed in association with renal transplant, autoimmune diseases and various hematological disorders, suggesting a certain immunosuppression may trigger a widespread abnormal keratinization.
Is porokeratosis malignant?
Porokeratosis is considered a premalignant condition, as all its variants have a potential for malignant transformation. The most common cancer is squamous cell carcinoma followed by basal cell carcinoma.
Is porokeratosis a rare disease?
Porokeratosis is a rare disease. The exact incidence and prevalence are not known. It typically occurs in adults or older adults with slight male predominance, but pediatric cases have been reported [3-7].
How common is disseminated superficial actinic Porokeratosis?
This is uncommon (< 10% of individuals with DSAP develop SCC). However, many patients with DSAP have had significant exposure to the sun and may also have actinic keratoses and other forms of skin cancer (particularly basal cell carcinoma).
What causes disseminated superficial actinic Porokeratosis?
DSAP is thought to be caused by a variety of factors. There is a genetic predisposition, but ultraviolet light exposure is thought to be the main cause. This condition tends to affect sun-exposed areas on people with fair skin who burn easily and tan poorly in the sun.