What is fludarabine and cyclophosphamide?
FCR is a combination of cancer drugs used to treat chronic lymphocytic leukaemia (CLL). It is made up of the drugs: fludarabine. cyclophosphamide.
What is fludarabine refractory chronic lymphocytic leukemia?
Fludarabine-refractory disease is defined as CLL that does not respond to fludarabine or that recurs within 6 months of treatment with a fludarabine-containing regimen. The natural course of the disease is associated with poor survival.
Is fludarabine alkylating agent?
Fludarabine is a purine analogue and antineoplastic agent. It is generally used as its 5-O-phosphorylated form known as fludarabine phosphate, sold under the brand name Fludara among others….Fludarabine.
| Clinical data | |
|---|---|
| CompTox Dashboard ( EPA ) | DTXSID2023060 |
| ECHA InfoCard | 100.123.703 |
| Chemical and physical data | |
| Formula | C10H12FN5O4 |
What is the mechanism of action of fludarabine?
Fludarabine is a chemotherapy drug used in the treatment of chronic lymphocytic leukemia. It acts at DNA polymerase alpha, ribonucleotide reductase and DNA primase, results in the inhibition of DNA synthesis, and destroys the cancer cells.
What are side effects of cyclophosphamide?
Cyclophosphamide may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- nausea.
- vomiting.
- loss of appetite or weight.
- abdominal pain.
- diarrhea.
- hair loss.
- sores on the mouth or tongue.
- changes in skin color.
What are the benefits of cyclophosphamide?
Cyclophosphamide is used to treat cancer of the ovaries, breast, blood and lymph system, and nerves (mainly in children). Cyclophosphamide is also used for retinoblastoma (a type of eye cancer mainly in children), multiple myeloma (cancer in the bone marrow), and mycosis fungoides (tumors on the skin).
Is fludarabine an immunosuppressant?
Fludarabine is a nucleoside analog used in the treatment of hematologic malignancies that can induce severe and prolonged immunosuppression.
Does cyclophosphamide cause hair loss?
Cyclophosphamide may cause a temporary loss of hair in some people. After treatment has ended, normal hair growth should return, although the new hair may be a slightly different color or texture.