What happens if you take too many bupropion?
In severe toxic doses it can cause coma, hypotension, multiple seizures, QRS widening, QTc prolongation, status epilepticus, and ventricular dysrhythmias [2]. Seizure due to intentional or unintentional overdose is among the most commonly reported toxic effect of bupropion [3–6].
Is Wellbutrin overdose fatal?
Associated cardiac toxicity includes sinus tachycardia, and massive overdose can cause widening of the QRS complex, ventricular dysrhythmias and cardiovascular collapse. Death can occur. Although reported data are limited, they suggest that less than 0.5% of reported cases of bupropion overdose result in death.
What does it feel like to overdose on bupropion?
After an overdose of bupropion, clinical effects are primarily on the neurological, cardiovascular and gastrointestinal systems. Neurological effects can include tremor, confusion, agitation, hallucination, coma, and seizures. Cardiovascular effects involve tachycardia and conduction defects.
What happens if you take 300 mg of bupropion?
See also Warning section. Dry mouth, sore throat, dizziness, nausea, vomiting, ringing in the ears, headache, decreased appetite, weight loss, constipation, trouble sleeping, increased sweating, or shaking (tremor) may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Can bupropion overdose cause brain damage?
Bupropion overdose is associated with a clinical examination demonstrating the absence of brainstem reflexes and the lack of a meaningful motor response, the combination of which can be suggestive of brain death in the proper clinical setting.
Is 600 mg of bupropion too much?
The maximum daily dose of bupropion is 450 mg, but reported cases of abuse have involved ingesting from 600 mg 8 to 1200 mg of the drug 2.
How long do the effects of a Wellbutrin overdose last?
Bupropion concentrations peak in less than 2 hours for immediate release preparations, but take as long as 5 hours with the modified-release formulations. Its half-life is 21 hours.
How likely is it to have a seizure on Wellbutrin?
Seizures: Bupropion is associated with seizures in approximately 0.4% (4/1,000) of patients treated at doses up to 450 mg/day. This incidence of seizures may exceed that of other marketed antidepressants by as much as 4-fold.
How many mg of bupropion is lethal?
Serious toxicity can be expected with doses > 6 g, and fatalities usually involve doses > 9 g.