What are the most common side effects of simvastatin?

The more common side effects that can occur with simvastatin include:

Table of Contents

headache.
nausea.
stomach pain.
constipation.
muscle pain or weakness.
joint pain.
upper respiratory infections.

Does simvastatin have a lot of side effects?

This medication may rarely cause liver problems. If you notice any of the following rare but serious side effects, tell your doctor right away: yellowing eyes/skin, dark urine, severe stomach/abdominal pain, persistent nausea/vomiting. A very serious allergic reaction to this drug is rare.

What drugs are affected by SLCO1B1?

The gene organic anion transporting polypeptide 1B1 (OATP1B1, also known as SLCO1B1) encodes the transmembrane protein OATP1B1, which transports anionic drugs such as statins, irinotecan, rifampin, repaglinide and methotrexate.

What is the disadvantage of taking simvastatin?

A warning that people taking statins may experience increased blood sugar levels and may develop type 2 diabetes. People taking statins should have their blood-sugar levels checked regularly.

What are the symptoms of statin myopathy?

Symptoms of statin induced myopathy include fatigue, muscle pain, muscle tenderness, muscle weakness, nocturnal cramping, and tendon pain. The muscle symptoms tend to be proximal, generalised, and worse with exercise.

What is SLCO1B1 gene?

The SLCO1B1 gene provides instructions for making a protein called organic anion transporting polypeptide 1B1, or OATP1B1. This protein is found in liver cells; it transports compounds from the blood into the liver so that they can be cleared from the body.

How do you fix statin muscle damage?

Although there are no proven remedies for statin-related muscle pain, the following may help.

Exercise.
Ramp up your lifestyle changes.
Have a thyroid blood test.
Take supplements.
Change your prescription.
Image: © Christophe Bourloton/Thinkstock.

Does statin muscle pain go away?

Muscle pain usually goes away within 1 to 2 weeks after you stop taking a statin. If the pain doesn’t go away, it may have been caused by something else.

Can you take vitamin D with statins?

Vitamin D supplement may have moderate or no effect on the dosage requirement or side effects of pravastatin, rosuvastatin and pitavastatin. Since vitamin D has mild HMG-CoA reductase activity, it will work synergistically with all statins.

Why do statins make your legs ache?

The researchers suggest that in most people, muscle cells can tolerate this calcium leak. However, in people already susceptible due to their genes or lifestyle, the leak caused by statins may overwhelm the muscle cells, giving rise to muscle pain and weakness.

How can I tell if statins are causing muscle pain?

Statin-related muscle pain, if it happens at all, usually happens within the first few months after you start the drug or raise the dose. You may feel a constant soreness or weakness in your shoulders, thighs, hips, or calves. If you’re like most people, it’ll affect both sides of your body equally.

What is the concentration of simvastatin associated with SLCO1B1*5?

In contrast, the concentration of simvastatin acid, was positively correlated with SLCO1B1*5 both at 20mg (p = 0.006) and 80mg (p = 0.03). This pattern, however, was not evident for pravastatin acid (p > 0.5).

Is pravastatin the best statin for carriers of SLCO1B1*5allele?

For these patients, our findings suggest that pravastatin – instead of simvastatin – may be a reasonable first choice statin for carriers of the SLCO1B1*5allele, whereas women may benefit from increased surveillance for symptoms.

Is SLCO1B1*5 genotype associated with mild Statin-induced muscle side effects?

Conclusions SLCO1B1*5 genotype and female sex were associated mild statin-induced side effects. These findings expand the results of a recent genome wide association study of statin myopathy with CK > 3 times normal to milder, statin-induced, muscle side effects.

What does it mean to have normal SLCO1B1?

Normal (high) function – This means there are two copies of the normal activity SLCO1B1 gene. This results in normal SLCO1B1 function. About 7 out of every 10 people have normal (high) function. There is no reason to use genetic test results to adjust the normal dose of medicines that are affected by SLCO1B1 if you are in this group.