What generation is desogestrel?
Desogestrel is a third-generation progestin with high progestational selectivity, minimizing androgenic effects and estrogenic activity. It shows a lower negative impact on metabolism, weight gain, acne, and other side effects typical of older progestins.
What generation is drospirenone?
The progesterone component of this oral contraceptive pill (OCP), drospirenone (DRSP), is a fourth-generation progestin that has potent progestogenic, antimineralocorticoid, and antiandrogenic activity, which are unique characteristics compared with the other progestogens contained in most of the other OCPs currently …
What does desogestrel do to your body?
The traditional progestogen-only pill (POP) prevents pregnancy by thickening the mucus in the cervix to stop sperm reaching an egg. The desogestrel progestogen-only pill can also stop ovulation. The progestogen-only pill needs to be taken every day to work.
What are the generations of progestin?
The first generation progestin includes norethindrone, lynestrenol, ethynodiol diacetate, and norethisterone. The second generation includes levonorgestrel, and norgestrel. And the third generation includes desogestrel, gestodene, and norgestodene.
Can desogestrel make you put on weight?
A review of 44 studies showed no evidence that birth control pills caused weight gain in most women. And, as with other possible side effects of the pill, any weight gain is generally minimal and goes away within 2 to 3 months.
Does desogestrel affect fertility?
No, long-term use of the pill or mini-pill won’t affect your fertility. If you’ve been taking the pill or mini-pill, your chances of getting pregnant within a year are about the same as any other couple.
What is a second generation progesterone?
The second generation includes levonorgestrel, and norgestrel. And the third generation includes desogestrel, gestodene, and norgestodene. Due to their causality with breast cancer, first-generation progestins are not used and have more side effects than the second and third generation ones (8).
What is a third generation pill?
Third-generation oral contraceptives are an association of low-dose ethinyl estradiol and potent testosterone-derived progestins, developed in order to improve general and vascular tolerance. They are highly efficient and well tolerated by most users.
What is 3rd Gen progesterone?
Desogestrel, gestodene, and norgestimate are 3 third generation progestins now available in Europe in combined oral contraceptives (OCs) containing ethinyl estradiol. The 3 gonane molecules all result from modifications in the structure of levonorgestrel which neutralize its androgenic activity.
Does desogestrel help acne?
“Recent studies on adult acne point to using a combined oral contraceptive pill with drosperinone, norgestimate and desogestrel, as being most effective for conquering adult acne.
Is desogestrel better than levonorgestrel?
Results: Desogestrel (150 micrograms/day) did not change serum total triglyceride concentration, whereas levonorgestrel (150 micrograms/day) decreased it. Except for monophasic ethinyloestradiol plus levonorgestrel, the oestrogen-containing combinations increased serum triglyceride level.
What are the second generation progesterone?
How is desogestrel metabolized?
Desogestrel, in combination with ethinyl estradiol, does not counteract the estrogen-induced increase in SHBG, resulting in lower serum levels of free testosterone (96-99). Desogestrel: Desogestrel is rapidly and completely metabolized by hydroxylation in the intestinal mucosa and on first pass through the liver to etonogestrel.
What is desogestrel used for?
Desogestrel is a third-generation progestin with high progestational selectivity, minimizing androgenic effects and estrogenic activity. It shows a lower negative impact on metabolism, weight gain, acne, and other side effects typical of older progestins. It shows positive effects on lipoproteins as seen by a slight rise of HDL cholesterol.
Does desogestrel cause weight gain?
Desogestrel is a third-generation progestin with high progestational selectivity, minimizing androgenic effects and estrogenic activity. It shows a lower negative impact on metabolism, weight gain, acne, and other side effects typical of older progestins.
Is estrostep more androgenic than desogestrel?
It tends to be less androgenic than the second-generation progestins, but more androgenic than newer progestins, like desogestrel. The brand Estrostep was designed to more closely mimic a woman’s natural menstrual cycle by providing increasing levels of estrogen with a constant progestin dose.