Is sitagliptin good for type 2 diabetes?
Sitagliptin is used along with diet and exercise and sometimes with other medications to lower blood sugar levels in adults with type 2 diabetes (condition in which blood sugar is too high because the body does not produce or use insulin normally).
Is sitagliptin an insulin?
Recently, sitagliptin, the first DPP-4 inhibitor launched on the market, has been approved for use in combination with insulin. Sitagliptin combined with insulin significantly reduces blood glucose levels over the four-hour period following the meal test.
Does sitagliptin reduce HbA1c?
At 24 weeks, sitagliptin treatment had significantly reduced HbA1c by 0.74% overall compared with placebo, with the most pronounced mean reduction in HbA1c (0.89%) seen in the group that had been treated with all three active drugs.
How does sitagliptin increase insulin?
Sitagliptin increases post-meal insulin secretion (“incretin effect) by enhancing the postprandial GLP-1 response (“incretin enhancer”), in a glucose-dependent manner.
What are the side effects of sitagliptin?
The more common side effects that can occur with sitagliptin include:
- upset stomach.
- diarrhea.
- stomach pain.
- upper respiratory infection.
- stuffy or runny nose and sore throat.
- headache.
How much does sitagliptin lower A1C?
Sitagliptin will decrease postprandial blood glucose and mildly lower fasting blood glucose for a total A1C reduction around 0.8 percent. It is more expensive than other options, such as sulfonylurea hypoglycemics.
What is the best time to take sitagliptin?
Take sitagliptin once a day. You can take it at any time, for example, in the morning or in the evening. But try to take it at the same time every day. Take your tablet with a drink of water.
What is the side effect of sitagliptin?
The most common side effects of JANUVIA include upper respiratory infection, stuffy or runny nose and sore throat, and headache. JANUVIA may have other side effects, including stomach upset and diarrhea, swelling of the hands or legs, when JANUVIA is used with metformin and rosiglitazone (Avandia ®).
Who should not use sitagliptin?
JANUVIA should not be used in patients with type 1 diabetes or with diabetic ketoacidosis (increased ketones in the blood or urine). If you have had pancreatitis (inflammation of the pancreas), it is not known if you have a higher chance of getting it while taking JANUVIA.
What is the safest pill for type 2 diabetes?
Most experts consider metformin to be the safest medicine for type 2 diabetes because it has been used for many decades, is effective, affordable, and safe. Metformin is recommended as a first-line treatment for type 2 diabetes by the American Diabetes Association (ADA).