What are the side effects of antihypertensive drugs?
Some common side effects of high blood pressure medicines include:
- Cough.
- Diarrhea or constipation.
- Dizziness or lightheadedness.
- Erection problems.
- Feeling nervous.
- Feeling tired, weak, drowsy, or a lack of energy.
- Headache.
- Nausea or vomiting.
What are the most common adverse reactions of antihypertensive agents?
Nausea, constipation, palpitation, swollen feet or legs, cold hands or feet, cramps, persistent dry cough, skin rash, frequent urination, and decreased sexual desires were associated with one or more of the following antihypertensive medications: furosemide, hydrochlorothiazide, amlodipine, nifedipine, atenolol, and …
Can antihypertensive drugs cause hypotension?
Angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) can also predispose to orthostatic hypotension, but this usually is the result of treating a patient who is already intravascularly volume-depleted and/or in whom the renin-angiotensin-aldosterone (RAA) system has been primed.
Which antihypertensive medications are most likely to cause tachycardia?
The three drugs available in this country are verapamil, diltiazem, and nifedipine. Pharmacological studies have shown that verapamil has the most negative chronotropic and inotropic effects of the three, with nifedipine producing the most vasodilation and having the potential for causing reflex tachycardia.
What are complications of high blood pressure?
Uncontrolled high blood pressure can lead to complications including: Heart attack or stroke. High blood pressure can cause hardening and thickening of the arteries (atherosclerosis), which can lead to a heart attack, stroke or other complications. Aneurysm.
Which antihypertensive drugs cause cough?
As important as the drugs are in treating conditions like heart failure and coronary artery disease, ACE inhibitors can cause side effects. One of the more common is a persistent dry cough.
What antihypertensive drugs cause postural hypotension?
Antihypertensive Medications and Other Cardiovascular Drugs Predisposing to Orthostatic Hypotension (OH)
- Diuretics. Diuretics are considered to be one of the main determinants of drug-related OH.
- α-Receptor Blockers.
- Nitrates.
- β-Blockers.
- Clonidine.
- Calcium Channel Blockers.
- ACE Inhibitors and Angiotensin II Receptor Blockers.
What is drug induced hypotension?
Orthostatic hypotension (OH) is a common side effect of drugs. It causes a reduction in blood pressure (BP) on standing, which results in reduced cerebral blood flow that is linked to falls, strokes, cognitive impairment, and increased mortality.
Does amlodipine cause tachycardia?
Amlodipine may induce sinus tachycardia via reflex-mediated increase in sympathetic tone. Such lack of reflex tachycardia with azelnidipine will provide potential therapeutic strategy for treatment of patients with cardiovascular diseases, being more beneficial than amlodipine.
Do ACE inhibitors cause tachycardia?
Adverse effects of ACE inhibitors include angioedema, persistent dry cough, altered taste, fatigue, headache, hyperkalemia, hypotension, photosensitivity, proteinuria, rash, tachycardia, and pancytopenia.
What are the contraindications of amlodipine?
Amlodipine is contraindicated in patients with known hypersensitivity to amlodipine or its dosage form components. In addition, amlodipine is relatively contraindicated in patients with cardiogenic shock, severe aortic stenosis, unstable angina, severe hypotension, heart failure, and hepatic impairment.
Does amlodipine cause bradycardia?
There is a very low reported incidence of amlodipine-induced bradycardia (0.89% of cases). Despite its infrequency, it is important to recognize amlodipine-induced bradycardia as simply discontinuing the drug will lead to complete resolution of symptoms.
What are complications of uncontrolled hypertension?
Uncontrolled hypertension increases the risk of heart attack, heart failure, kidney disease, stroke, and cognitive decline (1–3). Low control rates are partly explained by lack of awareness of hypertension; improving awareness could lead to improved control rates (4,5).
What is an abnormal complication of systemic hypertension?
Hypertension is a risk factor for all clinical manifestations of atherosclerosis since it is a risk factor for atherosclerosis itself. It is an independent predisposing factor for heart failure, coronary artery disease, stroke, kidney disease, and peripheral arterial disease.
Which antihypertensive causes dry cough?
A dry cough occurs in 10-15% of patients treated with ACE inhibitors, due to the accumulation of bradykinin, substance P and/or prostaglandin in the lungs (3), which coincides with our results. Thiazide diuretics are one of the cheapest and most commonly used antihypertensive drugs worldwide.
Which antihypertensive drug causes dry cough as side effect?
One of the more common side effects of ACE inhibitors is a persistent dry cough. The same activity that allows ACE inhibitors to lower blood pressure can cause other substances, like bradykinin, to accumulate in the airways.
What drug class is most likely to cause postural hypotension and thus an increased risk of falls?
Alpha-blockers such as doxazosin, prazosin, and terazosin cause blood vessels to dilate, thereby lowering blood pressure. They commonly cause orthostatic hypotension. Giving alpha-blockers at bedtime is a strategy to help reduce fall risk.
What causes postural hypotension?
Many conditions can cause orthostatic hypotension, including: Dehydration. Fever, vomiting, not drinking enough fluids, severe diarrhea and strenuous exercise with a lot of sweating can all lead to dehydration. Dehydration decreases blood volume.
Why does antihypertensives cause orthostatic hypotension?
Drugs can produce orthostatic hypotension by interfering with the autonomic pathways or their target end-organs or by affecting intravascular volume.