What is Bupivacaine Hydrochloride used for?
Bupivacaine injection is used to numb an area of your body during or after surgery or other procedures, childbirth, or dental work. This medicine is also used to numb your shoulder after surgery for up to 72 hours. It is a local anesthetic.
What drug class is bupivacaine?
Bupivacaine belongs to a group of drugs called local anesthetics.
What happens if bupivacaine is given IV?
IV bupivacaine can quickly lead to cardiotoxicity. A Black Box warning for bupivacaine notes that the drug can cause profound disturbances in cardiac rhythm and contractility that are resistant to typical resuscitation efforts, making these mix-ups particularly deadly.
What is the most toxic local anesthetic?
1). In anesthesia clinical practice, bupivacaine is known to have potent toxicity. It interrupts both metabotropic and ionotropic signal transduction. The toxicity of bupivacaine is more apparent in tissues with high aerobic demand and low tolerance for hypoxia.
What is the longest acting local anesthetic?
Bupivacaine HCl is approximately 90% to 95% bound to serum proteins, mostly to high-affinity, low-capacity sites on α1-acid glycoprotein. Because bupivacaine HCl is so highly protein bound, it was the longest-acting local amide anesthetic on the market, until the introduction of the liposomal formulation.
How long does a nerve block with bupivacaine last?
In dentistry, bupivacaine hydrochloride administered as a nerve block in adult humans has a duration of action of 6 to 8-hours, and 5 to 7-hours as a local infiltration.
Can nurses administer bupivacaine?
Bupivacaine is administered to patients by many healthcare professionals, including the surgeon, anesthesiologist, pain specialist, emergency department physician, and nurse practitioner.
Can you mix lidocaine and bupivacaine?
A combination of lidocaine and bupivacaine, plain or with epinephrine, is readily available in most Canadian health care settings where such procedures are performed, and fulfills these criteria. However, commercially available solutions of both medications are acidic and cause a burning sensation on injection.
Can bupivacaine be given IM?
Conclusion: A single intramuscular injection of bupivacaine induced dose-dependent increases in intramuscular glutamate levels and muscular damage.
https://www.youtube.com/watch?v=89f8W6Px-44&list=PLfZC7RnttBPg7yZbEDiI1a3PM3OCPdvMA